Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia

Table 3.

Semiquantitative grading scales of tau pathology

ROI	CA1	CA2-3	DG	Sm Ctx	Ent Ctx
Counts^{^a}
Scale^{^b}
0	0	0	0	0	0
0.5	1-2	1-2	1	1-2	1-2
1	3-4	3-4	2	3-4	3-4
1.5	5-9	5-6	3	5-9	5-9
2	10-14	7-8	4	10-14	10-14
2.5	15-19	9-10	5	15-19	15-19
3	≥20	≥11	≥6	≥20	≥20

↵^aCounts = the number of immunoreactive neuronal cell bodies identified within a single FOV.
↵^bScale = Semiquantitative unit in the y axes of Figure 8B-E.

Published online before print 4 May 2022, doi: 10.1523/JNEUROSCI.0543-22.2022 The Journal of Neuroscience 8 June 2022 vol. 42 no. 23 4737-4754

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