NRG1 decreases SW-R occurrence in wild-type hippocampus in vitro. A, Neuregulin 1 (NRG1) treatment paradigm. B, Representative filed potentials (FPs) in CA1 region at baseline, NRG1 treatment, and washout. C, Decreased sharp wave ripple (SW-R) occurrence by NRG1 (10 nm, blue), compared with baseline (black) and washout (purple). D, E, No effect on sharp wave length (D) or amplitude (E) by NRG1 (blue), compared with baseline (black) or washout (purple). F, Overlapped power spectrum density (PSD) distribution curves across different frequencies. Shown were representative curves of baseline (black), NRG1 (blue), and washout (purple). G, No effect of NRG1 on ripple power between 150 and 300 Hz. H, Similar heatmap of (PSD) of SW-R events from baseline (left), NRG1 (center), and washout (right; n = 6 slices, 6 wild-type mice). Error bars indicate SEM. n.s., not significant. *p < 0.05.