Neuregulin 1 and ErbB4 Kinase Actively Regulate Sharp Wave Ripples in the Hippocampus

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Figure 6.
Figure 6.

1NMPP1 increases SW-R occurrence in the dHPC CA1 in vivo. A, Schematic of electrode implantation and recording. Tetrodes were implanted into the dorsal hippocampus (dHPC) of T796G mice. B, Schematic of treatment and recording paradigms. C, Example traces of raw LFP (1–500 Hz, top) and ripples after filtering at 150–250 Hz (bottom). D, Increased SW-R occurrence by 1NMPP1 (red) compared with vehicle (black). E, No effect on SW-R length by 1NMPP1 (red) compared with vehicle (black). F, Overlapped power spectrum density (PSD) distribution curves across different frequencies. G, No effect by 1NMPP1 (red) compared with vehicle (black) on SW-R power. H, PSD heatmap of SW-R events from vehicle (top) and 1NMPP1 (bottom).Error bars indicate SEM. n.s., not significant. *p < 0.05.

  1. The Journal of Neuroscience vol. 42 no. 3 390-404
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