1NMPP1 increases overall neuronal firing, PyN baseline, SW-R burstiness, and SW-R fold change. A, Schematic waveform characteristics. B, Pseudocolored heatmap of spike waveform characteristics [firing rate Hertz (Hz), trough-to-peak milliseconds (ms), and half-valley width (ms)] of putative PyN probability (Gaussian mixture model, k = 2, n = 175). C, Example of autocorrelograms of putative pyramidal (PyN) (red, top) and putative interneurons (INs) (blue, bottom), as well as waveform from putative PyN (red) and putative INs (blue). D, Increased overall firing rate after 1NMPP1 (red) addition compared with vehicle (black). E, No effect of 1NMPP1 (red) on IN overall firing compare to vehicle (black). F, Increased PyN firing rate after 1NMPP1 (red) compared with vehicle (black). G, No alteration of PyN neuron per SW-R of 1NMPP1 (red) compared to vehicle (black). H, Probability of PyN interspike interval (ISI) during SW-R events of vehicle (black) and 1NMPP1 (red). I, Decreased maximal PyN SW-R ISI probability of 1NMPP1 (red) compared with vehicle (black). J, Decreased PyN SW-R firing fold change of 1NMPP1 (red) compared with vehicle (black).Error bars indicate SEM. n.s., not significant. *p < 0.05. **p < 0.01. ***p < 0.001.