Excitation of GABAergic interneurons by ChR2-positive DGCs is necessary for eIPSCs. A, C, Current traces represent eIPSCs in mature DGCs before and during bath application of a GABAA receptor antagonist, SR95531 (10 μm), or a non-NMDA receptor antagonist, DNQX (20 μm). B, D, Summary of the changes in eIPSC amplitude by GABAA receptor antagonist and non-NMDA receptor antagonist. SR95531 and bicuculline (30 μm) were used in 3 and 4 mature DGCs, respectively, and the results from these 7 DGCs were combined. Replicates are DGC number. Open circles and black solid circles represent the results from individual cells and averages, respectively. Data are mean ± SEM. *p < 0.05. ***p < 0.001.
