Reduced microgliosis with increased astrocytic response in the brains of prion-infected neuronal Hrs-depleted mice. A, Representative hematoxylin and eosin (HE) prion-infected Hrs^f/fSyn1-Cre⁻ and Cre⁺ brain sections (thalamus). Iba1 (microglia)-immunolabeled (B, C) and GFAP (astrocytes)-immunolabeled (D, E) brain sections and quantification of labeled area (thalamus; n = 3–4 Hrs^f/fSyn1-Cre mice/group). Scale bar = 100 µm. Data shown as mean ± SEM. Unpaired, two-tailed Student's t test, **p < 0.01. Data supported by Extended Data Figure 3-1.