Hypothalamic Supramammillary Nucleus Selectively Excites Hippocampal CA3 Interneurons to Suppress CA3 Pyramidal Neuron Activity

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 5.
Figure 5.

Pseudotyped rabies virus tracing reveals the monosynaptic projection from SuM to PV+ neurons in CA3. A, Experimental procedure and timeline. B, Top left, Sample confocal image represents the viral injection site in dorsal CA3 from a PV-Cre mouse. Top right, Expanded view represents a starter cell (mCherry+/GFP+) that is also immunopositive for PV staining (arrowhead). Bottom, Expanded views of the starter cell. C, Sample confocal images represent mCherry+ cells observed in SuM (top). Two mCherry+ cells in SuM shown in the expanded views (bottom). D, Sample confocal image represents the viral injection site in dorsal CA3 from a SOM-Cre mouse. E, No mCherry+ cells detected in SuM (repeated in 4 SOM-Cre mice).

  1. The Journal of Neuroscience vol. 43 no. 25 4612-4624
Responses to This Article
Be the first to respond to this article
Advertisement