Inhibition of dopamine neurons suppresses lever-cue elicited locomotion. Data are mean ± SEM. a, Average velocity (cm/s) of movement during the 4-s period immediately before and immediately on lever-cue presentation. b, Distance (cm) from the lever-cue for the 2-s period immediately before and immediately on lever-cue presentation. c, Latency to approach the food magazine immediately following lever-cue retraction. a, Control rats moved faster when the lever-cue was presented, relative to the period before lever-cue presentation. Control rats also moved quicker than eNpHR rats that received inhibition of dopamine neurons when the lever-cue was presented. b, Control rats moved closer to the lever-cue when it was presented relative to eNpHR rats that received inhibition of dopamine neurons. c, eNpHR rats that received lever-paired inhibition of dopamine neurons were delayed in approaching the food magazine on lever-cue retraction. *p < 0.05. ***p < 0.001.