Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents

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Figure 3.
Figure 3.

Normal brain metabolism from birth until adulthood derived from [18F]-FDG PET: conflicting results between older and more recent studies. The blue line represents the mean local cerebral metabolic rate of glucose in the whole brain, derived from studies published before 2000 (H.T. Chugani and Phelps, 1986; H.T. Chugani et al., 1987; Kinnala et al., 1996). The red line represents the mean maximum standard uptake value (SUV) in different brain regions, derived from studies published between 2014 and 2018 (London and Howman-Giles, 2014; Barber et al., 2018). The horizontal line with large and small dots represents the adult values of mean local cerebral metabolic rate of glucose and SUV, respectively.

  1. The Journal of Neuroscience vol. 43 no. 49 8275-8293
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