Cognitive Aging and the Primate Basal Forebrain Revisited: Disproportionate GABAergic Vulnerability Revealed

Table 6.

Volume of ChAT and GAD67 immunopositive cells in basal forebrain of young and aged behaviorally characterized monkeys

Cell volume (µm3)
Young Aged DR-AU DR-AI DNMS-AU DNMS-AI
ChAT+ cells 6732 7155 7115 7186 6959 7407
(SE; n) (459; 8) (371; 16) (499; 7) (559; 9) (506; 9) (572; 7)
Rostral ChAT+ cells 5739 5890 5838 5931 5785 6026
(SE; n) (700; 8) (391; 16) (426; 7) (635; 9) (532; 9) (619; 7)
Caudal ChAT+ cells 6998 7691 7607 7757 7471 7974
(SE; n) (407; 8) (386; 16) (610; 7) (529; 9) (544; 9) (567; 7)
GAD67+ cells 1953 2351* 2419 2274 2523* 2201
(SE; n) (119; 7) (110; 15) (203; 7) (61; 8) (192; 8) (106; 7)
Rostral GAD67+ cells 1659 2097* 2161 2024 2295* 1924
(SE; n) (81; 7) (134; 15) (247; 7) (80; 8) (249; 8) (106; 7)
Caudal GAD67+ cells 2141 2538* 2602 2463 2682* 2411
(SE; n) (115; 7) (105; 15) (185; 7) (88; 8) (169; 8) (169; 7)
  • ↵*p < 0.05 relative to young.

  1. The Journal of Neuroscience vol. 43 no. 49 8425-8441
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