Pol II stalling and RNA expression at selected G4-DNA sites. A, Proposed model of G4-DNA and Pol II interaction during transcription associated with memory formation. Comparing total RNA from SC and DHX36 shRNA-treated EXT mice (see Extended Data Fig. 7-1 for more details) showed that there was a significant decrease in (B) Rims4 (t₍₆₎ = 4.416, **p < 0.01), (C) Kcnmb4 (t₍₆₎ = 3.007, *p < 0.05), (D) Rictor (t₍₆₎ = 4.479, **p < 0.01), (E) Yy1 (t₍₆₎ = 3.135, *p < 0.05), (F) Syne2 (t₍₆₎ = 2.618, *p < 0.05), (G) Add1 (t₍₆₎ = 4.026, **p < 0.01), (H) Chl1 (t₍₆₎ = 5.175, **p < 0.01), and (I) Gphn (t₍₆₎ = 3.797, **p < 0.01). Pol II–bound RNA increased in (J) Rims4 (t₍₅₎ = 1.448, p = 0.1036), (K) Kcnmb4 (t₍₅₎ = 1.906, p = 0.0537), (L) Rictor (t₍₅₎ = 1.833, p = 0.0631), (M) Yy1 (t₍₅₎ = 2.451, *p < 0.05), (N) Syne2 (t₍₅₎ = 1.691, p = 0.0758), (O) Add1 (t₍₅₎ = 1.629, p = 0.0821), (P) Chl1 (t₍₅₎ = 1.630, p =0.0820), and (Q) Gphn (t₍₅₎ = 3.351, *p < 0.05).