Monosynaptic Rabies Tracing Reveals Sex- and Age-Dependent Dorsal Subiculum Connectivity Alterations in an Alzheimer's Disease Mouse Model

Table 3.

Data summary of CSI and PI measurements

WT young WT middle 5xFAD young 5xFAD middle
Mean SEM Mean SEM Mean SEM Mean SEM
CSI summary
 CA1_py 37.7953 5.2921 31.5000 4.3837 40.7620 2.3022 13.8835 1.3216
 CA1_or 1.2013 0.3422 1.2242 0.2206 0.8664 0.1782 0.5687 0.1026
 CA1_rad 0.1160 0.0193 0.2302 0.0286 0.0985 0.0314 0.1216 0.0318
 CA1_lmol 0.1093 0.0401 0.0628 0.0147 0.0632 0.0247 0.1024 0.0263
 CA2_py 0.8291 0.0965 0.7376 0.2225 0.8725 0.0868 0.4024 0.0506
 CA2_or 0.0296 0.0093 0.0234 0.0072 0.0583 0.0127 0.0438 0.0130
 CA3_py 1.0087 0.5901 0.3927 0.1854 0.6763 0.3820 0.3453 0.2308
 CA3_or 0.0475 0.0128 0.0413 0.0074 0.0748 0.0133 0.0686 0.0112
 SUB 10.1783 1.2574 6.5282 0.5425 8.8363 0.9168 7.4721 0.7437
 PostSUB 0.9515 0.2478 0.9427 0.4536 1.4021 0.5041 0.9485 0.3778
 MS-DB 1.3175 0.1816 1.0204 0.1924 0.9410 0.1071 0.4593 0.0628
 Thalamus 0.9022 0.2451 0.4653 0.0931 0.7509 0.1263 0.3354 0.1102
 RSC 1.7979 0.4588 0.9879 0.3911 1.4492 0.3497 0.6619 0.2547
 Vis cortex 1.2750 0.7136 2.8280 1.5745 5.2217 1.6207 0.5301 0.2877
 Aud Cortex 0.6859 0.4599 0.7486 0.5241 0.8048 0.2012 0.0672 0.0390
 SS Cortex 0.0676 0.0329 0.0575 0.0416 0.0221 0.0078 0.0224 0.0123
 TeA 1.1864 1.0377 0.3050 0.1541 0.3566 0.0686 0.0888 0.0291
 Prh 0.4073 0.1505 0.1088 0.0256 0.2884 0.0872 0.1620 0.0475
 Ect 0.2519 0.0940 0.0863 0.0268 0.2362 0.0678 0.1280 0.0474
 LEC 0.4429 0.1457 0.3485 0.0905 0.2719 0.1078 0.3179 0.0902
 MEC 0.7852 0.2759 0.4092 0.2281 0.5234 0.1567 0.5871 0.1493
PI summary
 CA1_py 58.4838 3.1812 64.8701 2.4048 63.0325 1.8142 51.0676 2.1452
 CA1_or 1.9183 0.4506 2.6308 0.4665 1.3955 0.2988 2.0883 0.3278
 CA1_rad 0.2115 0.0556 0.5114 0.0625 0.1582 0.0507 0.4526 0.0978
 CA1_lmol 0.1877 0.0578 0.1572 0.0393 0.1127 0.0514 0.4002 0.1152
 CA2_py 1.4048 0.1801 1.4068 0.2230 1.4031 0.1889 1.5151 0.2089
 CA2_or 0.0518 0.0136 0.0575 0.0171 0.0980 0.0227 0.1640 0.0518
 CA3_py 1.7384 0.9727 1.1501 0.6257 1.2584 0.7657 1.3853 1.0092
 CA3_or 0.0716 0.0149 0.0992 0.0186 0.1258 0.0258 0.2486 0.0324
 SUB 16.8789 1.8477 14.8686 1.5137 13.8588 1.4307 27.5509 1.5691
 PostSUB 1.7476 0.5280 1.5225 0.4565 2.1249 0.7269 3.0727 1.0010
 MS-DB 2.2173 0.3269 2.1018 0.1580 1.4978 0.1909 1.6799 0.1509
 Thalamus 1.7093 0.4501 1.0427 0.2103 1.1849 0.2234 1.1212 0.2969
 RSC 2.8141 0.6319 1.7410 0.3970 2.1658 0.4382 2.2247 0.6888
 Vis cortex 1.9859 0.9604 4.1163 1.4331 7.6444 2.2371 2.2177 1.2674
 Aud cortex 0.6553 0.3533 0.9941 0.4759 1.2035 0.2885 0.2911 0.1738
 SS Cortex 0.0920 0.0435 0.0767 0.0383 0.0343 0.0122 0.0864 0.0531
 TeA 0.9889 0.7338 0.4625 0.1840 0.5486 0.1165 0.2889 0.0871
 Prh 0.6574 0.2115 0.2642 0.0875 0.4744 0.1725 0.5506 0.1024
 Ect 0.3258 0.0775 0.1735 0.0408 0.3472 0.0884 0.4090 0.1204
 LEC 0.7472 0.2130 0.8340 0.2597 0.4807 0.2291 1.0881 0.2779
 MEC 1.4215 0.5267 0.9189 0.5871 0.8505 0.2668 2.0971 0.5510
# of mice 8 10 10 12
# of starters 95 20 101 17 65 15 132 17
# of total labeled neurons 5,357 729 4,218 546 4,064 699 3,739 509
Overall connectivity 69 11 51 8 67 3 29 2

  • The data summary of CSI and PI values for WT young, WT middle-age, 5xFAD young, and 5xFAD middle-age mice. Data are presented as mean ± SEM.

  1. Published online before print 19 March 2024, doi: 10.1523/JNEUROSCI.1796-23.2024 The Journal of Neuroscience vol. 44 no. 16
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