Monosynaptic Rabies Tracing Reveals Sex- and Age-Dependent Dorsal Subiculum Connectivity Alterations in an Alzheimer's Disease Mouse Model

Table 6.

Statistical comparisons of CSI and PI values between sexes

WT young male versus WT young female WT middle male versus WT middle female 5xFAD young male versus 5xFAD young female 5xFAD middle male versus 5xFAD middle female
p value Significance p value Significance p value Significance p value Significance
CSI comparison
 CA1_py 0.7857 0.8413 >0.9999 0.4318
 CA1_or 0.3929 0.5476 0.0190 * 0.8763
 CA1_rad 0.2500 0.8413 0.2571 0.6755
 CA1_lmol 0.2500 0.3095 0.6095 0.8763
 CA2_py 0.2500 0.3095 0.0667 0.2677
 CA2_or 0.7857 0.0317 * 0.7095 0.6389
 CA3_py 0.1250 >0.9999 0.0381 * 0.4318
 CA3_or 0.2500 0.0079 ** 0.5714 0.6389
 SUB >0.9999 0.0317 * 0.1143 0.5030
 PostSUB 0.0714 0.4206 0.0190 * 0.2020
 MS-DB 0.0357 * 0.3095 0.9143 0.8763
 Thalamus 0.1429 >0.9999 0.1143 0.0732
 RSC 0.5714 0.6905 0.1143 0.1490
 Vis cortex >0.9999 0.2222 0.7619 0.4318
 Aud cortex 0.4464 0.0952 0.9413 0.0922
 SS cortex 0.3750 >0.9999 0.8000 0.1263
 TeA >0.9999 0.4206 0.9143 0.6755
 Prh 0.2500 0.4206 0.7619 0.0101 *
 Ect 0.2500 >0.9999 0.7619 0.2020
 LEC 0.5714 0.2222 0.3238 0.0303 *
 MEC >0.9999 0.2222 0.0381 * 0.0303 *
PI comparison
 CA1_py 0.0714 >0.9999 0.4762 0.8763
 CA1_or >0.9999 0.8413 0.0381 * 0.8763
 CA1_rad 0.7857 0.6905 0.2571 0.4318
 CA1_lmol 0.3929 0.4206 0.6095 0.7551
 CA2_py 0.5714 0.5476 0.0381 * 0.2020
 CA2_or 0.3929 0.0556 >0.9999 0.6389
 CA3_py 0.2321 >0.9999 0.0667 0.3434
 CA3_or >0.9999 0.0317 * 0.3524 0.3434
 SUB 0.5714 0.0317 * 0.2571 >0.9999
 PostSUB 0.0357 * 0.4206 0.0381 * 0.2677
 MS-DB 0.5714 >0.9999 >0.9999 0.4318
 Thalamus 0.1429 0.6905 0.2571 0.1490
 RSC 0.3929 0.5476 0.1143 0.2677
 Vis cortex >0.9999 0.0556 >0.9999 0.4318
 Aud cortex 0.4464 0.0952 >0.9999 0.0922
 SS cortex 0.7857 >0.9999 0.8000 0.1263
 TeA >0.9999 0.2222 0.9143 0.6755
 Prh 0.3929 0.1508 0.9143 0.0051 **
 Ect 0.2500 0.6905 0.7619 0.3434
 LEC 0.5714 0.1508 0.2381 0.0303 *
 MEC >0.9999 0.2222 0.1714 0.0177 *

  • The data summary of CSI and PI value comparisons between sexes for WT young, middle-age, 5xFAD young, and 5xFAD middle-age mice. Statistical significances are denoted by *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001. Statistical method: Wilcoxon rank-sum test.

  1. Published online before print 19 March 2024, doi: 10.1523/JNEUROSCI.1796-23.2024 The Journal of Neuroscience vol. 44 no. 16
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