SW/SWR events are modulated by GABAA and AMPA but not by NMDA receptor signaling
| Drug exposure, n | SW abundance (/min; mean ± SEM) | p value | SW amplitude (µV; mean ± SEM) | p value | SW duration (ms; mean ± SEM) | p value | %SWR abundance (/min; mean ± SEM) | p value | Ripple power (µV2; mean ± SEM) | p value |
|---|---|---|---|---|---|---|---|---|---|---|
|
aCSF 30 µM AP-5 N = 8 |
24.36 ± 4.625 19.19 ± 2.890 |
0.2169 |
17.11 ± 6.175 15.32 ± 4.212 |
0.7101 |
441.1 ± 53.61 446.0 ± 55.92 |
0.8945 |
18.87 ± 5.651 17.96 ± 7.323 |
0.8945 | ||
|
aCSF 5 µM NBQX + 25 µM AP-5 N = 4 |
23.50 ± 4.481 0.000 ± 0.000 |
0.0135* | ||||||||
|
aCSF 30 µM BMI N = 7 |
27.14 ± 6.319 28.39 ± 6.287 |
0.8585 |
18.84 ± 5.252 20.42 ± 6.457 |
0.5503 |
212.2 ± 36.71 287.1 ± 39.56 |
0.0027** |
7.307 ± 1.472 22.79 ± 5.716 |
0.0182* |
5.549 ± 0.613 7.594 ± 0.969 |
0.0486* |
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Electrophysiology recordings were done at baseline (aCSF) and continued upon drug exposure. Changes in the abundance, amplitude, and duration of SW events were measured for AP-5 and BMI. Since NBQX abolished events, no further analyses were done. % SWR (SW/SWR*100) abundance was measured for AP-5 and BMI. Ripple power was further measured for BMI. Paired Student's t tests were performed.
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*p < 0.05, **p < 0.005.
