5-HT1 receptor signaling modulated acquisition and recall of nOR memories. A, Timeline for testing the effects of WAY-100635 plus GR-127935 (5-HT1A and 5-HT1B antagonists, respectively, WAY plus GR) microinjection into CA1 prior to training (acquisition group) or prior to testing (retrieval group) on nOR performance. B, nOR performance. There were no significant differences between saline-treated rats during acquisition or retrieval; therefore, these data were combined (n = 10/sex per control group). WAY plus GR given into dorsal CA1 during nOR acquisition (n = 10/sex) enhanced nOR performance in females only, whereas WAY plus GR given before the nOR retrieval test (n = 10/sex) reduced nOR performance in both males and females. †† indicates all the groups that are significantly different, p < 0.05. The asterisk indicates the significant difference between indicated groups, p < 0.05. C, Total time interacting with novel (colored bars) and familiar (gray bars) objects in the nOR task. Individual data points are plotted for novel object times only.
