ABC treatment in the mPFC alters intrinsic properties of FSIs. A, Timeline of treatment. B, Description of parameters. C, ABC treatment attenuated neuronal excitability as current steps increased. Number of rats (number of cells), 1 h, Veh N = 7 (15); ABC N = 4 (12); 3 d, Veh N = 10 (17); ABC N = 7 (9). D, Representative traces at 500 pA for the four experimental groups. E, There were no differences in firing variability at 1 h in either treatment group. Number of rats (number of cells), 200 pA, Veh N = 7 (13); ABC N = 4 (11); 500 pA, Veh N = 7 (15); ABC N = 4 (12). F, There were no differences in firing variability at 3 d in either treatment group. Number of rats (number of cells), 200 pA, Veh N = 10 (17); ABC N = 7 (10); 500 pA, Veh N = 10 (17); ABC N = 7 (10). G, ABC treatment increased membrane capacitance at both 1 h and 3 d. H, Input resistance was increased at 3 d versus 1 h. I, There were no differences in RMP at 1 h or 3 d in either treatment group. J, There were no differences in the AP half-width at 1 h or 3 d in either treatment group. K, ABC treatment reduced the AP threshold at both 1 h and 3 d. L, The AP amplitude was increased at 3 d versus 1 h in both groups. M, There were no differences in the AHP amplitude at 1 h or 3 d in either treatment group. N, ABC treatment increased the first ISI time at 1 h, but not at 3 d. O, Rheobase current was reduced at 3 d versus 1 h. Data are mean ± SEM. For (H–O) the number of rats (number of cells), 1 h, Veh N = 7 (15); ABC N = 4 (12); 3 d, Veh N = 10 (17); ABC N = 7 (9). *p < 0.05. Extended Data Figure 5-1 shows statistical comparisons for Figure 5.