Blockade of GluN2B-Containing NMDA Receptors Prevents Potentiation and Depression of Responses during Ocular Dominance Plasticity

Table 1.

mEPSC properties and recording conditions in NR, 2 d MD, 6 d MD + vehicle, and 6 d MD + Ro 25-6981 groups (related to Fig. 1)

Amplitude (pA) Frequency (Hz) Rise (ms) Decay (ms) Rin (MW) Rs (MW) RMS N
NR Ipsi 13.3 ± 0.4 7.87 ± 0.6 0.76 ± 0.02 2.56 ± 0.1 273 ± 13 16.8 ± 0.3 1.84 ± 0.02 27, 5
Contra 13.3 ± 0.4 8.90 ± 0.6 0.75 ± 0.02 2.56 ± 0.1 294 ± 12 16.2 ± 0.3 1.82 ± 0.02 29, 5
Statistic t(54) = 0.06 t(54) = 1.2 U = 390.5 t(54) = 0.03 U = 289 t(54) = 1.2 U = 358.5
p 0.95 0.22 0.99 0.97 0.09 0.2 0.59
2 d MD Ipsi 13.5 ± 0.4 7.71 ± 0.5 0.80 ± 0.03 2.79 ± 0.1 305 ± 19 16.4 ± 0.4 1.81 ± 0.02 30, 6
Contra 11.9 ± 0.3 9.06 ± 0.6 0.83 ± 0.03 2.85 ± 0.1 297 ± 18 16.5 ± 0.4 1.79 ± 0.02 32, 6
statistic t(60) = 2.9 t(60) = 1.7 U = 467 U = 458.5 U = 451 t(60) = 0.35 t(60) = 0.66
p 0.005* 0.10 0.86 0.77 0.69 0.73 0.51
6 d MD vehicle Ipsi 12.3 ± 0.4 6.69 ± 0.5 0.81 ± 0.02 2.67 ± 0.1 307 ± 33 16.0 ± 0.4 1.81 ± 0.02 23, 5
Contra 13.4 ± 0.3 6.98 ± 0.5 0.78 ± 0.02 2.70 ± 0.1 271 ± 14 16.6 ± 0.3 1.81 ± 0.02 28, 5
statistic t(49) = 2.6 U = 308 t(49) = 0.81 U = 305 U = 258.5 t(49) = 1.2 t(49) = 0.007
p 0.012* 0.80 0.42 0.75 0.23 0.26 0.99
6 d MD Ro 25-6981 Ipsi 13.8 ± 0.3 7.40 ± 0.5 0.82 ± 0.03 2.77 ± 0.1 282 ± 13 16.1 ± 0.4 1.80 ± 0.02 24, 5
Contra 12.4 ± 0.4 7.49 ± 0.6 0.85 ± 0.02 2.89 ± 0.1 318 ± 19 16.9 ± 0.5 1.81 ± 0.02 27, 5
Statistic t(49) = 2.8 t(49) = 0.11 t(49) = 0.92 t(49) = 1.09 U = 249.5 t(49) = 1.1 t(49) = 0.30
p 0.0075* 0.91 0.36 0.28 0.16 0.3 0.77
  • For each treatment, data were compared between control (ipsi) and deprived (contra) hemispheres using two-tailed unpaired t tests (t statistic reported) or Mann–Whitney tests (U statistic reported), as indicated. Bold values indicate significant differences. Data are shown as mean ± SEM. N is reported as cells, mice.

  • *p < 0.005.

  1. The Journal of Neuroscience vol. 44 no. 36
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