Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing

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Figure 3.
Figure 3.

sEPSC heterogeneity did not depend on the number of PF stimulations. a–c, Peak amplitude of sEPCS were similar in lobules IV/V, lobule X, and the flocculus in response to three, four, and five PF stimulations, respectively at 100 Hz. d–f, sEPSC time of peak was faster in lobules IV/V in response to three, four, or five PF stimulations at 100 Hz. g–i, sEPSC decay time was longer in lobule X than lobules IV/V in response to three PF stimulations at 100 Hz and longer in lobule X in comparison with both lobules IV/V and the flocculus in response to four or five PF stimulations at 100 Hz. Statistical comparisons: (b, e, f, h) *p < 0.05, **p < 0.01, ****p < 0.0001, ordinary one-way ANOVA followed by Tukey's multiple-comparison test. a, c, d, g, i, *p < 0.05, **p < 0.01, ***p < 0.001, Kruskal–Wallis test followed by Dunn's multiple-comparisons test. Violin plots show median and quartiles. (a, d, g: lobules IV/V = 3 cells from 3 mice, lobule X = 8 cells from 3 mice, flocculus = 5 cells from 2 mice. b, e, h: lobules IV/V = 5 cells from 3 mice, lobule X = 7 cells from 3 mice, flocculus = 10 cells from 5 mice. c, f, i: lobules IV/V = 5 cells from 3 mice, lobule X = 7 cells from 3 mice; flocculus = 11 cells from 5 mice). Additional details on statistics are in Extended Data Table 1.

  1. The Journal of Neuroscience vol. 44 no. 37
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