Figure 12.
E-cadherin expression is significantly reduced in the Tuba1a-Cre;Elp1loxp/loxp cKO colon epithelium. A, Quantification of FITC-dextran assay for gut leakiness shows an increased trend in FITC leakage across the gut wall in the cKOs compared with controls (ns = 0.121) n = 16 control, n = 14 cKO. B, Representative immunofluorescence (IF) images of E-cadherin (green) and DAPI (blue). C, Quantification shows a significant reduction in epithelial area stained for E-cadherin in FD mice. Unpaired t test, **p = 0.007, n = 3. Scale bar, 100 µm. See Extended Data Figure 11.1 for more details.
