ELP1, the Gene Mutated in Familial Dysautonomia, Is Required for Normal Enteric Nervous System Development and Maintenance and for Gut Epithelium Homeostasis

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 5.
Figure 5.

Loss of Elp1 in the adult Tuba1a-Cre;Elp1loxp/loxp cKO ENS causes an increase in myenteric neuron cell bodies. A, B, The number of Hu+ neurons (green) was determined in whole mounts of the ileum myenteric plexus of the adult Tuba1a-Cre;Elp1loxp/loxp cKO and control mice; unpaired t test p = 0.0280, control n = 4, cKO n = 5 mice; 10 images/mouse quantified with a 20× objective.

  1. The Journal of Neuroscience vol. 44 no. 37
Responses to This Article
Be the first to respond to this article
Advertisement