This Week in The Journal
Revealing Beta Amyloid Mechanisms of Action in Alzheimer's Disease
Olga Prikhodko, Ronald Freund, Emily Sullivan, Matthew Kennedy, and Mark Dell’Acqua
(see article e0675242024)
Beta amyloid buildup is a primary mediator of Alzheimer's disease (AD) pathology. Thus, insight into the mechanisms through which it disrupts synaptic activity and contributes to cell death is invaluable. In this issue, Prikhodko et al. discovered how beta amyloid causes glutamatergic NMDA receptor dysfunction and drives dendritic spine loss. Building off previous studies demonstrating that calcineurin signaling contributes to beta amyloid toxicity, the authors …
