Shown is the mouse nucleus tractus solitarius (nTS), a brain area that processes reflexive heart rate, blood pressure, and respiratory responses to stressful bodily or environmental triggers. The image highlights a neural pathway that strengthens nTS output and cardiorespiratory responses to low oxygen levels in the body. This pathway involves corticotropin-releasing hormone (CRH) neurons (red), likely from the paraventricular nucleus of the hypothalamus, extending into the nTS and interacting with presynaptic inputs (marked with synaptophysin, blue) that target inhibitory GABA neurons (green). See the article by Procopio Barcellos-Filho et al. for more information on the different ways CRH affects neuron populations in the nTS to enhance the cardiorespiratory response to low oxygen levels. Cover image: Procopio Barcellos, Heather Dantzler, and David Kline.