Neurobiology of Disease

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  1. Visualizing Synaptic Disruptions in the Release and Regulation of Dopamine Hotspots in Huntington's Disease
    • Sarah J. Yang,
    • Natsumi Komatsu,
    • Brendan Butler,
    • Jackson Travis Del Bonis-O'Donnell,
    • Francesca Giordani,
    • Ashvin Irrinki,
    • David V. Schaffer,
    • and Markita P. Landry
    Journal of Neuroscience, 7 October 2026, 46(40):e1862242026; published ahead of print September 15, 2026, doi:10.1523/JNEUROSCI.1862-24.2026
  2. Astrocytic 4R-tau Pathology Drives Aquaporin-4 Mislocalization, Glymphatic Dysfunction, and Neurotransmitter Dysregulation in Mice
    • Menglan Lu,
    • Haiyan Tian,
    • Jiuqi Wang,
    • Renyi Feng,
    • Haojie Meng,
    • Lilan Zhu,
    • Chi Qin,
    • Yukui Zhang,
    • and Xuejing Wang
    Journal of Neuroscience, 7 October 2026, 46(40):e2184252026; published ahead of print August 19, 2026, doi:10.1523/JNEUROSCI.2184-25.2026
  3. Cell type-specific assessment of cholesterol distribution in models of neurodevelopmental disorders
    • Shirley Dixit,
    • Charlotte Czernecki,
    • Isabelle Riezman,
    • Sabrina Innocenti,
    • Caroline Bornmann,
    • Laurent Guérard,
    • Frank W. Pfrieger,
    • Howard Riezman,
    • and Peter Scheiffele
    Journal of Neuroscience, e1339262026; published ahead of print October 6, 2026, doi:10.1523/JNEUROSCI.1339-26.2026
  4. Tracking the Continuous Time Dynamics of Tau and Depressive Symptoms across the Alzheimer's Disease Continuum
    • Teodora Z. Markova,
    • Margo B. Heston,
    • Anne S. Berry,
    • and for the Alzheimer’s Disease Neuroimaging Initiative
    Journal of Neuroscience, 9 September 2026, 46(36):e2309252026; published ahead of print August 24, 2026, doi:10.1523/JNEUROSCI.2309-25.2026
  5. Trans-dimerization of Amyloid Precursor Protein family members induces pre- and postsynaptic differentiation through distinct signaling pathways
    • Ritu Rajender,
    • Natalie Foth,
    • Simone Eggert,
    • Sandra Schilling,
    • Moritz Fäßler,
    • Caroline Ott,
    • Timo Mühlhaus,
    • Frederik Sommer,
    • Michael Schroda,
    • Tanja Maritzen,
    • Marija Banicevic,
    • Verena Bengelsdorff,
    • Eva Kiss,
    • Christian J. Buchholz,
    • Ulrike C. Müller,
    • and Stefan Kins
    The Journal of Neuroscience, e0701252026; published ahead of print June 23, 2026, doi:10.1523/JNEUROSCI.0701-25.2026
  6. Unilateral striatal deep brain stimulation improves cognitive control
    • Elizabeth M Sachse,
    • Evan M Dastin-van Rijn,
    • Jon P Bennek,
    • Michelle C Buccini,
    • Megan E Mensinger,
    • Francesca A Iacobucci,
    • Adriano E Reimer,
    • and Alik S Widge
    The Journal of Neuroscience, e1925252026; published ahead of print June 18, 2026, doi:10.1523/JNEUROSCI.1925-25.2026
  7. Stage- and Region-Dependent Proteomic Alterations in a Mouse Model of Creatine Transporter Deficiency
    • Shingo Ito,
    • Yumi Iwata,
    • Tatsuki Uemura,
    • Michihiko Sugimoto,
    • Haruka Kumabe,
    • Ayaka Miyano,
    • Teruya Nakamura,
    • Naoto Tashiro,
    • Megumu Ieiri,
    • Moeka Umezaki,
    • Shoma Chikamatsu,
    • Takeshi Masuda,
    • Satohiro Nakao,
    • Naomi Nakagata,
    • Toru Takeo,
    • Kimi Araki,
    • and Sumio Ohtsuki
    The Journal of Neuroscience, e2010252026; published ahead of print June 17, 2026, doi:10.1523/JNEUROSCI.2010-25.2026
  8. Disrupted maternal care alters neural-microglia interactions in the primate paralaminar (PL) nucleus of the amygdala
    • Dennisha P. King,
    • Mayesa Khan,
    • Ania K. Majewska,
    • Judy L. Cameron,
    • and Julie L. Fudge
    The Journal of Neuroscience, e0017262026; published ahead of print June 11, 2026, doi:10.1523/JNEUROSCI.0017-26.2026
  9. Alyref Deficiency Exacerbates Chronic Inflammatory Pain by Impairing Nuclear Export of Ccn3 mRNA
    • Yuxuan Shui,
    • Jian Zhang,
    • Shuxin Li,
    • Hanlin Wang,
    • and Sheng-Jian Ji
    The Journal of Neuroscience, e0356262026; published ahead of print June 4, 2026, doi:10.1523/JNEUROSCI.0356-26.2026
  10. COMMD1 Induces Copper Deficiency of SOD1 by Inhibiting the Palmitoylation of CCS in ALS
    • Xiaoli Su,
    • Xingli Tan,
    • Ying Wang,
    • Weiwei Liang,
    • Di Wang,
    • Di Huo,
    • Hongyong Wang,
    • Yan Qi,
    • Wenmo Zhang,
    • Ling Han,
    • Dongmei Zhang,
    • Ming Wang,
    • Jing Xu,
    • Shuyu Wang,
    • Jing Wang,
    • and Honglin Feng
    The Journal of Neuroscience, e1803252026; published ahead of print May 19, 2026, doi:10.1523/JNEUROSCI.1803-25.2026
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