The spatio-temporal dynamics of phoneme encoding in aging and aphasia
- 1Department of Psychology, Stanford University, Stanford, CA, USA
- 2Experimental Oto-Rhino-Laryngology, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium
- Correspondence should be addressed to Jill Kries at jill.kries{at}stanford.edu
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Author contributions: Conceptualization: JK, LG; Data Acquisition: JK, MV; Project. Administration: JK; Data Curation: JK; Resources: MV, LG; Methodology: LG, JK; Formal analysis: JK, LG; Visualization: JK; Writing – Original Draft Preparation: JK; Writing – Review and Editing: JK, MV, LG; Supervision: LG; Funding Acquisition: MV, LG.
Abstract
During successful language comprehension, speech sounds (phonemes) are encoded within a series of neural patterns that evolve over time. Here we tested whether these neural dynamics of speech encoding are altered for individuals with a language disorder. We recorded EEG responses from human brains of 39 individuals with post-stroke aphasia (13♀/26♂) and 24 healthy age-matched controls (i.e., older adults; 8♀/16♂) during 25 minutes of natural story listening. We estimated the duration of phonetic feature encoding, speed of evolution across neural populations, and the spatial location of encoding over EEG sensors. First, we establish that phonetic features are robustly encoded in EEG responses of healthy older adults. Second, when comparing individuals with aphasia to healthy controls, we find significantly decreased phonetic encoding in the aphasic group after shared initial processing pattern (0.08-0.25s after phoneme onset). Phonetic features were less strongly encoded over left-lateralized electrodes in the aphasia group compared to controls, with no difference in speed of neural pattern evolution. Finally, we observed that healthy controls, but not individuals with aphasia, encode phonetic features longer when uncertainty about word identity is high, indicating that this mechanism - encoding phonetic information until word identity is resolved - is crucial for successful comprehension. Together, our results suggest that aphasia may entail failure to maintain lower-order information long enough to recognize lexical items.
Significance statement This study reveals robust decoding of speech sound properties, so-called phonetic features, from EEG recordings in older adults, as well as decreased phonetic processing in individuals with a language disorder (aphasia) compared to healthy controls. This was most prominent over left-hemispheric electrodes. Additionally, we observed that healthy controls, but not individuals with aphasia, encode phonetic features longer when uncertainty about word identity is high, indicating that this mechanism - encoding phonetic information until word identity is resolved - is crucial for successful language processing. These insights deepen our understanding of disrupted mechanisms in a language disorder, and show how the integration between language processing levels works in the healthy aging, neurotypical brain.
Footnotes
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No conflicts of interest, financial or otherwise, are declared by the authors.
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The authors would like to thank all participants, especially all the brave participants with aphasia and their partners, family or friends that support them. Moreover, the authors would like to thank everyone who helped with data collection and recruitment: Dr. Pieter De Clercq, Dr. Klara Schevenels, Janne Segers, Rosanne Partoens, Charlotte Rommel, Dr. Ramtin Mehraram, Ines Robberechts, Laura Van Den Bergh, Anke Heremans, Frauke De Vis, Mouna Vanlommel, Naomi Pollet, Kaat Schroeven, Pia Reynaert, and Merel Dillen.
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↵*shared last author
- Received May 21, 2025.
- Revision received November 20, 2025.
- Accepted December 3, 2025.
- Copyright © 2025 Kries et al.
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