| Supplementary Data |
|
|
| Table II Genes altered in mice lacking
TNFa
|
|
| following demyelination and during
remyelination
|
|
|
|
|
|
|
|
| Accession # |
Demyelination |
Remyelination |
Function |
Gene name |
|
| Other genes |
|
|
|
|
| AI851708 |
-4 |
PA |
methylation |
(N6-adenosine)-methyltransferase |
|
| AI314990 |
1 |
6 |
metabolic |
Atp7a, MNK, copper-transporting ATPase |
|
| M77497 |
-3 |
1 |
cell death |
CYP2F; cytochrome P-450 |
|
| U08439 |
-2 |
PA |
cell death |
cytochrome c oxidase, subunit VIa |
|
| AF067660 |
1 |
-3 |
cell survival |
Diva, Bcl-2 family member |
|
| Z14050 |
1 |
-4 |
enzyme |
dodecenoyl-CoA delta isomerase |
|
| AB016780 |
1 |
-3 |
glucosamine synthesis |
Glutamine:fructose-6-phosphate amidotransferase 2 |
|
| AF088983 |
-3 |
1 |
stress response |
HSP40-3; heat shock protein |
|
| AI882416 |
-4 |
1 |
metabolism |
Leptin |
|
| D50434 |
2 |
-3 |
cell adhesion |
MAdCAM-1 |
|
| AF042487 |
3 |
2 |
ion transport |
mIK1; intermed. conductance K channel |
|
| AW122482 |
4 |
1 |
mitochondrial |
mitochondrial F0 complex, subunit c |
|
| AW048260 |
-3 |
-3 |
mitochondrial |
Mitochondrial ribosomal protein 63 (MRP63) |
|
| X54149 |
1 |
-6 |
stress response/DNA damage |
MyD118; DNA-damage-inducible 45 beta |
|
| AJ242909 |
3 |
1 |
metabolism |
N-Acetylglucosamine kinase |
|
| U28151 |
-13 |
PA |
cell migration |
p130Cas; Crk-associated substrate |
|
| AV147906 |
1 |
-3 |
electron transport |
P4hb, cellular thyroid hormone binding protein |
|
| D17583 |
3 |
1 |
endoproteolytic processing |
Proprotein convertase subtilisin/kexin type 5 |
|
| AW209486 |
3 |
4 |
prostate antigen |
Prostate stem cell antigen (PSCA) |
|
| AA414947 |
23 |
2 |
proteasome-related |
proteasome regulatory complex p44.5 |
|
| AB003305 |
1 |
-3 |
proteasome-related; pseudogene |
psmb5-ps |
|
| AV007820 |
1 |
-6 |
calcium-binding |
S100 calcium binding protein A13 |
|
| AA683883 |
1 |
3 |
mitochondrial |
Slc25a10; mitochondrial carrier |
|
| AV367494 |
-3 |
-2 |
chromatin remodeling |
Smarcd2; Swi/Snf-related |
|
| AV324302 |
5 |
2 |
cholesterol biosynthesis |
squalene epoxidase |
|
| AU044050 |
1 |
6 |
cell cycle |
thymidylate synthase |
|
|
|
|
|
|
|
| Unknown |
|
|
|
|
| AV312736 |
4 |
-10 |
unknown |
0610010E05Rik |
|
| AI787183 |
3 |
1 |
unknown |
0610011I04Rik |
|
| AW120625 |
1 |
3 |
unknown |
0610042A05Rik |
|
| AW120971 |
2 |
10 |
unknown |
1100001J13Rik |
|
| AI448024 |
2 |
5 |
unknown |
1600014E20Rik |
|
| AA670737 |
2 |
3 |
unknown |
1700013L23Rik |
|
| C76819 |
PA |
2 |
unknown |
1810054D07Rik |
|
| AA710635 |
PA |
1 |
unknown |
2200003J09Rik |
|
| AI645662 |
5 |
-2 |
unknown |
2310020D06Rik |
|
| AV256163 |
-4 |
-4 |
unknown |
2310038G18Rik |
|
| AI021091 |
1 |
-6 |
unknown |
2310058A11Rik |
|
| AI843845 |
1 |
-4 |
unknown |
2310061B02Rik |
|
| AW045413 |
15 |
1 |
unknown |
2410012M21Rik |
|
| AW120816 |
PA |
PA |
unknown |
2510027D20Rik |
|
| AI844711 |
3 |
2 |
unknown |
2810426M17Rik |
|
| AW121234 |
1 |
-3 |
unknown |
2810442O16Rik |
|
| AV313633 |
-2 |
3 |
unknown |
3200002M19Rik |
|
| AI851708 |
-4 |
PA |
unknown |
5730589K01Rik |
|
| AI844771 |
7 |
1 |
unknown |
6330407G11Rik |
|
| AI843114 |
-4 |
10 |
unknown |
C80248 |
|
| AW124843 |
-12 |
8 |
unknown |
C85108 |
|
| AA790291 |
-2 |
-3 |
unknown |
D5Ertd135e; similar to radixin |
|
| AV333522 |
1 |
-4 |
unknown |
D7Wsu180e |
|
| AI835016 |
1 |
4 |
unknown |
Expressed sequence AU040608 |
|
| AI462038 |
1 |
-3 |
unknown |
similar to relaxin |
|
| AW124470 |
-14 |
-4 |
unknown |
Slc25a17; Tm4sf7 Transmembrane 4 superfamily |
|
| AA798076 |
7 |
3 |
unknown |
|
|
| AA919832 |
4 |
-2 |
unknown |
|
|
| AI842588 |
3 |
1 |
unknown |
|
|
| AI849705 |
14 |
2 |
unknown |
|
|
| AV173777 |
1 |
-3 |
unknown |
|
|
| AV174603 |
4 |
2 |
unknown |
|
|
| AV350479 |
4 |
1 |
unknown |
|
|
| AW124933 |
1 |
-3 |
unknown |
|
|
| AW048311 |
PA |
-4 |
unknown |
|
|
| AA870525 |
1 |
5 |
unknown |
|
|
| AI451701 |
-3 |
1 |
unknown |
|
|
| AI835098 |
PA |
PA |
unknown |
|
|
| AI852034 |
1 |
4 |
unknown |
|
|
| AI853899 |
-7 |
-2 |
unknown |
|
|
