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Files in this Data Supplement:

• Supplementary Table 1 - Transcripts altered in demyelinated and remyelinating lesions. Affymetrix gene chip analysis was performed on corpus callosum RNA from wild-type mice at time points representing normal levels of myelin, complete demyelination, and active remyelination. Gene expression data are presented for the demyelinated and remyelinating time points as fold changes above or below (shown in red as a negative value) the expression data for the untreated mice. Only those genes with a raw value of > 1000 in at least one condition, a > 3-fold change in expression, a standard error of < 0.4 of the normalized values in duplicate experiments were included for analysis. AP denotes that the expression of that gene was absent in untreated samples and present in treated sample while PA denotes a gene went from present in untreated samples to absent in treated samples. Genes were grossly categorized according to their function, with genes of unknown function or functions outside of our main categories appearing here as supplementary data.
• Supplementary Table 2 - Genes altered in mice lacking TNFa following demyelination and during remyelination. Affymetrix gene expression data from corpus callosum of wild-type mice were compared to that of TNFa-/- mice with similar treatments. The data are shown for TNFa-/- mice as fold changes above or below (shown in red as a negative value) their counterpart wild-type mice. Only those genes with a raw value of > 1000 in at least one condition, a > 3-fold change in expression, a standard error of < 0.4 of the normalized values in duplicate experiments were included for analysis. AP denotes that the expression of that gene was absent in untreated samples and present in treated sample while PA denotes a gene went from present in untreated samples to absent in treated samples. Genes were grossly categorized according to their function, with genes of unknown function or functions outside of our main categories appearing here as supplementary data.