Corticotropin-Releasing Factor and Somatostatin Neurons in the Central Amygdala Mediate Dynamic Defensive Behaviors during Fear Extinction

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Figure 4.
Figure 4.

CRF+ CEA inhibition during extinction attenuates post-extinction freezing to tone during recall in the threat context. A, Comparison of average freezing during the tone period in the neutral context of Recall1 for all CRF-Cre groups. B, Comparison of average freezing during the tone period in the threat context of Recall2 for all CRF-Cre groups. C, Comparison of average freezing during the white noise (WN) period in the neutral context of Recall1 for all CRF-Cre groups. D, Comparison of average freezing during the WN period in the threat context of Recall2 for all CRF-Cre groups. E, Comparison of average speed during the tone period in the neutral context of Recall1 for all CRF-Cre groups. F, Comparison of average speed during the WN period in the threat context of Recall2 for all CRF-Cre groups. ChR2: n = 9, Control: n = 8, eNpHR3: n = 9. Data from all figures are presented as mean ± SEM and were analyzed with one-way ANOVA and Tukey's multiple-comparisons test. *p < 0.05, **p < 0.01.

  1. The Journal of Neuroscience vol. 46 no. 14
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