Corticotropin-Releasing Factor and Somatostatin Neurons in the Central Amygdala Mediate Dynamic Defensive Behaviors during Fear Extinction

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Figure 5.
Figure 5.

SOM+ CEA neuron excitation replaces early flight to white noise with freezing. A, Freezing during the tone period for all SOM-Cre groups. B, Comparison of average freezing during the tone period for all SOM-Cre groups between the first and last 4-trial bins of Extinction. C, Freezing during the white noise (WN) period for all SOM-Cre groups. D, Comparison of average freezing during the WN period for all SOM-Cre groups between the first and last 4-trial bins of Extinction. E, Speed during the WN period for all SOM-Cre groups. F, Comparison of average speed during the WN period for all SOM-Cre groups between the first and last 4-trial bins of Extinction. G, Comparison of average speed during the WN period for all SOM-Cre groups during the first four trials of Extinction. ChR2: n = 10, Control: n = 10, eNpHR3: n = 9. Data for A–F is presented as mean ± SEM and were analyzed using two-way ANOVA and Tukey's/Sidak's multiple-comparisons test when appropriate. Data for G is presented as mean ± SEM and were analyzed using one-way ANOVA and Tukey's multiple-comparisons test. **p < 0.01, ****p < 0.0001.

  1. The Journal of Neuroscience vol. 46 no. 14
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